Scrum-half Aidan Sezer (hand injuiry) and prop Matt Prior (suspended) are ruled out from the team which beat Castleford Tigers last week.
With four props, both half-backs and their first-choice hooker all unavailable, Rhinos are down to the bare bones.
Coach Rohan Smith has named a 20-man squad, but what could his matchday 17 look like? Here's a prediction.
1. Full-back: ZakHardaker.
If he's passed fit, Hardaker could move to his favoured role at No 1, allowing for a reshuffle elsewhere. Photo: Bruce Rollinson
2. Wing: David Fusitu'a.
The New Zealand/Tonga powerhouse is an option at full-back or centre, but wing is his preferred position. Photo: Alan Whitehead/SWpix.com.
3. Centre: Rhyse Martin.
Has played centre several times this year and in the circumstances is a logical choice to do the job again. Photo: Bruce Rollinson
4. Centre: Liam Sutcliffe.
Might be moved into the halves, but has been outstanding at centre in the pasty two games. Photo: Bruce Rollinson
5. Wing: Ash Handley.
Another option at full-back or centre, but given his recent try-scoring feats, it makes sense for him to continue on the left-wing. Photo: Jonathan Gawthorpe
6. Stand-off: Corey Johnson
Liam Sutcliffe has played at six in the past, but Johnson did a good job against Castleford last week. Photo: Allan McKenzie/SWpix.com